Representation of symptom alleviation

ABSTRACT

Systems and methods are provided for generating dynamic representations of symptoms and symptom alleviation.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. patent application Ser. No.15/980,086 filed May 15, 2018, which is a continuation of InternationalPatent Application No. PCT/US2016/062348, filed Nov. 16, 2016, whichclaims the benefit of U.S. Provisional Patent Application No. 62/255,946filed Nov. 16, 2015, the disclosures of which are incorporated herein byreference in their entirety.

BACKGROUND OF THE INVENTION 1. The Field of the Invention

Suitable management of symptoms (e.g., pain) of adverse healthconditions can help patients have better lives. The mind is an integralpart of the pain experience in any patient, human or animal. When apatient's perception is influenced, the whole psychology of pain, indeedthe whole experience of the pain, can change dramatically, even if thesource of the pain itself is not influenced. The same is true for manyother symptoms. For example, mirror therapy is shown possessing power ofusing real visual input to provide significant, lasting relief frompain. Mirror therapy is based on observing a virtual recovery of amissing limb or a recovery of function in an affected body part in amirror, and can lead to a reduction in the perceived pain. Nevertheless,mirror therapy has its limitations. Mirror therapy using a mirror boxcan be cumbersome, and mirror therapy, in general, is more effectivewhen there is a visual cue for the pain, such as a missing limb. Manytypes of pain, such as headaches or back pain, don't have a relatedvisible cue.

It would be helpful to have a new paradigm of methods and systems thatprovide a patient with a virtual, yet realistic and strongly impactfulrepresentation of the patient's symptoms and their alleviation, becausethis would further stimulate the patient's mind to change perception ofpain and symptom alleviation.

BRIEF SUMMARY OF THE INVENTION

The technologies disclosed herein include methods, systems, and storagemedia for symptom (e.g. pain) management based on multimediatechnologies. The disclosed methods and systems create amultidimensional sensory environment, further creating various sensoryobjects or forms to represent a symptom within the sensory environment.The technologies further allow the user to simulate various healthimproving schemes through interaction with the sensory representationsof the symptom. The technologies allow the user to sense potentialeffects of the health improvements, leading to a change in psychologicalperception of the symptom and its improvement. Applications of thetechnologies can enable pain reduction, support physical therapy ofstroke victims or neurodegenerative illness, treat other physical andpsychological disorders, and improve other symptoms.

Besides using the disclosed technologies to sense potential healthimprovement, a patient can learn a behavioral technique for dealing witha health issue. For example, in the use of the technologies for thealleviation of chronic pain due to an irreversible condition, the usercan use the technologies to learn how to apply mental coping strategiesfor perceiving the pain and its broader role in the patient's life.

In one aspect, a method of representing symptoms and symptomsalleviation is provided. The method comprises creating, by one or moreprocessors, a first digital model for generating a sensory environmentcomprising first sensory signals; causing an output device to executethe first digital model to generate the sensory environment; creating asecond digital model for a symptom, wherein the second digital modelcauses generation of second sensory signals; causing the output deviceto generate the second sensory signals within the sensory environmentbased on the second digital model; creating a third digital model of analleviation or removal of the symptom based on the first or the seconddigital models, wherein the third digital model causes generation ofthird sensory signals, and wherein at least a portion of the secondsensory signals and/or third sensory signals change continuously overtime to human perception; and causing the output device to generate thethird sensory signals within the sensory environment based on the thirddigital model.

In some embodiments, the output device comprises multiple devices andthe first sensory signals, second sensory signals, and third sensorysignals are individually or collectively sent to one or more of themultiple devices. In some embodiments, the first sensory signals, secondsensory signals, or third sensory signals form holographic,virtual-reality, or augmented-reality representations. In someembodiments, the output device produces audio, visual, tactile, orolfactory signals. In some embodiments, the first sensory signals,second sensory signals, or third sensory signals are produced responsiveto user input.

In some embodiments, the method further comprises receiving adescription of the symptom, wherein creating the second digital model isbased on the description. In some embodiments, the description of thesymptom comprises one or more of a photo, a video, an animation, asound, a vibration, or a scent. In some embodiments, the sensoryenvironment includes a user interface for providing a description of thesymptom or selecting from a set of predefined descriptions. In someembodiments, the description is for various pain types, including one ormore of aching, throbbing, sore, stabbing, shooting, stabbing, cramping,gnawing, splitting, heavy, or burning.

In some embodiments, the second digital model is modified to representchanges in qualities of the symptom, including duration, intensity,frequency, depth, topography, sharpness, or appearance. In someembodiments, the method further comprises modifying the second digitalmodel responsive to user input.

In some embodiments, the sensory environment includes an avatar of auser. In some embodiments, a view of the avatar corresponds to afirst-person view or a third-person view for the user. In someembodiments, the avatar switches between the first- and third-personviews.

In some embodiments, the method further comprises modifying the firstdigital model to generate a change to the avatar responsive to userinput. In some embodiments, the second or third sensory signals aregenerated on or within the avatar.

In some embodiments, the method further comprises determining a symptomalleviation method, wherein creation of the third digital model is basedon the symptom alleviation method. In some embodiments, the symptomalleviation method includes parameters comprising a duration, intensity,manner, or quality of symptom alleviation.

In some embodiments, the third digital model corresponds to one or moreof: a reduction in size of; an increase of a distance from; anevaporation of; a recoloring/discoloration of; a dilution of; adiffusion of; a dissipation of; a relocation of; a reduction infrequency of; a distortion of; a disappearing of; a washing or blowingaway of; a removal of; a throwing away of; a silencing of; a slowing of;a melting of; a healing of; a stilling of; or a cooling of the symptom.

In some embodiments, the third digital model corresponds to creating aset of stimuli, which leads the user to experience changes in bodyself-perception or an out-of-body experience. In some embodiments, thethird sensory signals creates a sensation within the user of the mind orconsciousness of the user leaving the user's body and floating above orbeside the user's body, the mind or consciousness moving from one bodyto another, a part of the body leaving the main body, or one or moresymptoms leaving the body.

In another aspect, a method of representing symptom alleviation isprovided. The method comprises receiving information regardingalleviating a symptom, including a selection from a plurality ofpredetermined modes for representing symptom alleviation; generating adigital model for alleviating the symptom based on the receivedinformation; and managing a symptom alleviation experience based on thereceived information. In some embodiments, the plurality ofpredetermined modes includes a passive mode, an active mode, or aresponsive mode, wherein when the selection is the passive mode, themanaging includes sending the digital model to an output device andcausing the output device to generate sensory signals based on thedigital model, wherein when the selection is the active mode, themanaging includes receiving user instructions from an input device, andwherein when the selection is the responsive mode, the managing includesreceiving biometric data from a sensor device. In some embodiments, whenthe selection is the active or responsive mode, the managing furtherincludes updating the digital model based on the user instructions oruser biofeedback. In some embodiments, the biofeedback includes a heartrate, heart rate variability, breathing, galvanic skin response, brainwaves, EEG signals, fMRI signals, or muscle tension.

In some embodiments, the method further comprises receiving aspecification of a symptom alleviation method; generating a simplifiedversion of the first, second, or third digital model, and sending thespecification and the simplified version to a remote device over acommunication network.

In some embodiments, the third digital model includes verbal or visual auser, including skills for coping with the symptom or affirmations onthe user's power to control or alleviate the symptom.

In another aspect, a system for representing symptoms and symptomalleviation is provided. The system comprises a processor; and a memoryoperatively coupled to the processor and configured for storing datainstructions that, when executed by the processor, cause the system toperform a method, the method comprising: creating a first digital modelfor generating a sensory environment comprising first sensory signals;causing an output device to execute the first digital model to generatethe sensory environment; creating a second digital model for a symptom,wherein the second digital model causes generation of second sensorysignals; causing the output device to generate the second sensorysignals within the sensory environment based on the second digitalmodel; creating a third digital model of an alleviation or removal ofthe symptom based on the first or the second digital models, wherein thethird digital model causes generation of third sensory signals, andwherein at least a portion of the second sensory signals and/or thirdsensory signals change continuously over time to human perception; andcausing the output device to generate the third sensory signals withinthe sensory environment based on the third digital model.

In some embodiments, the output device is a head mounted virtual realitydisplay, augmented reality display, monitor, speaker, haptic device,holographic display, smart wearable device, or a smart handheld device.

In yet another aspect, a non-transitory computer-readable storage mediumwith instructions stored thereon that, when executed by a processor,cause the processor to perform a method of representing symptoms andsymptom alleviation is provided. The method comprises creating, by oneor more processors, a first digital model for generating a sensoryenvironment comprising first sensory signals; causing an output deviceto execute the first digital model to generate the sensory environment;creating a second digital model for a symptom, wherein the seconddigital model causes generation of second sensory signals; causing theoutput device to generate the second sensory signals within the sensoryenvironment based on the second digital model; creating a third digitalmodel of an alleviation or removal of the symptom based on the first orthe second digital models, wherein the third digital model causesgeneration of third sensory signals, and wherein at least a portion ofthe second sensory signals and/or third sensory signals changecontinuously over time to human perception; and causing the outputdevice to generate the third sensory signals within the sensoryenvironment based on the third digital model.

BRIEF DESCRIPTION OF THE DRAWINGS

The present disclosed technologies are illustrated by way of example,and not by way of limitation, in the figures of the accompanyingdrawings and in which like reference numerals refer to similar elementsand in which:

FIG. 1 illustrates an exemplary environment in which the systemdisclosed in the present application can operate.

FIG. 2 illustrates an exemplary functional structure of the system.

FIG. 3 describes exemplary operations of the system disclosed herein.

FIG. 4 illustrates an exemplary presentation of or interaction with asensory environment.

FIG. 5A illustrates an exemplary user operation to provide a symptomdescription.

FIG. 5B illustrates an exemplary user operation to provide a furthersymptom description by managing a digital model of the symptom.

FIG. 6 illustrates an exemplary user operation to edit or adjustfeatures of symptom alleviation.

FIG. 7 illustrates an exemplary digital model of symptom improvement, ina passive mode.

FIG. 8 illustrates an exemplary digital model of symptom alleviation, inan active mode.

FIG. 9 illustrates an exemplary digital model of a symptom withdifferent types of sensory signals.

FIG. 10 illustrates an exemplary computing architecture applicable toany computing device discussed herein.

The novel features of the disclosed technologies are set forth withparticularity in the appended claims. A better understanding of thefeatures and advantages of the present invention will be obtained byreference to the following detailed description that sets forthillustrative embodiments, in which the principles of the invention areutilized.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

Unless otherwise defined, all technical terms used herein have the samemeaning as commonly understood by one of ordinary skill in the art towhich this invention belongs. As used in this specification and theappended claims, the singular forms “a,” “an,” and “the” include pluralreferences unless the context clearly dictates otherwise. Any referenceto “or” herein is intended to encompass “and/or” unless otherwisestated.

A “sensory environment” described herein means a computer generatedenvironment or a computer enhanced environment (e.g. augmented reality)comprising sensory signals representing a context, for representingsymptoms and symptom alleviation processes. For example, the sensoryenvironment can include representations of a room or landscape, avatars,virtual control panels, etc. Further details and embodiments of thesensory environment are described below.

“Sensory Signals” (also referred to as a “sensory representation” or a“representation”) described herein means any signal which can stimulateor impact the human (or animal) senses, eyes, ears, skin, nose, limbs,body, brain, mind or nervous system. Examples include but are notlimited to: audio, visual, tactile, or olfactory signals. They alsoinclude signals which can impact the human (or animal) body, brain ornervous system without being consciously perceived; for example,transcranial direct current stimulation. In some preferred embodiments,the sensory signals are created in or in combination with virtualreality, augmented reality, or holography. Further details andembodiments of the sensory signals are described below.

A “symptom” described herein means any psychological or physical healthaspect, particularly those related to pain, injury, physical orpsychological suffering, illness or disease. Further details andembodiments of the symptom are described below.

“Out-of-Body Experience” (OBE) described herein means a phenomenon inwhich a person typically experiences a sensation of the consciousnessleaving the body. Often the person experiences a sensation of floatingabove/beside the body. One way to manifest this experience is to providethe user with a view of an avatar (virtual self) representing the userin a virtual reality environment from a third-person perspective suchthat the avatar appears to be about two meters in front of the user.Using virtual reality controllers, the user can move the limbs of theavatar. The user is given a series of actions and activities which leadthe user to self-identify with the avatar, even though the user sees itfrom a third-person perspective. In addition to the active influence theuser has on the virtual-reality environment, other objects in thevirtual-reality environment interact with the avatar and the real self;for example, an object in the virtual environment hits the avatar. Atthe same time, the user feels a strong pulse in a haptic vest worn bythe user in a location corresponding to the place the avatar was hit.This illusion creates a paradox in the user's brain between visual andtactile signals. The user sees the user's virtual self two meters aheadbut experiences touch in the real physical location. This can lead to anout-of-body type of experience. Another method for manifesting theout-of-body experience is to start the user in a first person view inthe avatar, allowing the user to engage in various activities andinteract with the virtual-reality environment, including receivingtactile response. This allows the user's brain to self-identify with theavatar and to geo-locate the position of the avatar. The view of theavatar to the user is then moved from a first-person view out of thebody into a third-person view; however, the user maintains control overthe movements of the avatar and continues to receive tactile feedback.The user's brain will often continue to self-identify and geo-locate theavatar, leading to a sense of the consciousness having left the body andcontrolling it from afar (or the body having left the consciousnessbehind). Further details and embodiments of the OBE are described below.

“Self-Perception” described herein means a mechanism in which the brain(consciousness) identifies with and locates the physical body.Self-perception also includes a mechanism by which the brain identifiesand locates different parts of the body (e.g. where is the right arm;where is the right arm in relation to the torso). Self-perception can befully or partially manipulated in OBE. Examples of how such manipulationcan be manifested are explained in the definition of OBE above. Furtherdetails and embodiments of the self-perception are described below.

Regardless of whether a visual cue or source of the symptom (e.g. pain)is known, the technologies can be applied. Unlike mirror therapy basedsolutions for pain, the present technologies allow users (e.g.,patients) or their helpers (e.g., family members, physicians orcomputing systems) to create digital models of symptom (e.g., pain,malady, wound), even if there is no physical manifestation of thesymptom, such as a missing or injured limb or some other injury.Furthermore, the disclosed technologies can enable creation of sensorsignals to form an immersive environment, such as a virtual reality oran augmented reality environment, that more readily enables the brain toaccept the offered stimuli as real and that allows subjects to believeimprovements in their symptoms (e.g., relieving pain) or trust their ownpower to control the improvement.

In various embodiments, the systems, methods, media disclosed hereininclude a computing system, or use of the same. FIG. 1 illustrates anexemplary computing environment in which the system disclosed in thepresent application can operate. The system 101 comprises one or moreprocessors and one or more memories. FIG. 2 illustrates exemplarymodules of the system. Referring to FIG. 2, a system 200 comprises auser interface 201 receiving inputs from user and generating outputs tothe user. The system 200 further comprises a data processing and modelmanagement module 202. The module 202 processes input data from theuser, a helper (e.g. physician, computer), or other devices, performsanalysis and generates digital models for symptoms, symptom alleviationmethods, etc. for transmission to output devices that are capable ofproducing sensory signals. The module 202 uses a series of rules oralgorithms to effectively change, move, reduce, remove, or improverepresentations of symptoms. The system 200 further comprises an outputdevice interface 203 to communicate with output devices, includingtransmitting the digital models to the output devices.

These modules can be implemented as general or specific-purposehardware, software, or firmware (or any combination thereof) components.For example, a general computer executes computing instructions of thetechnologies, or a customized computing device (e.g., FPGA, ASIC,Raspberry, industrial computer, etc.) is implemented to realize thetechnologies disclosed herein. Modules are typically functionalcomponents that can generate useful data or other output using specifiedinput(s). A module may or may not be self-contained. A module can beoptional. Depending upon implementation-specific or otherconsiderations, the modules may be centralized or distributedfunctionally or physically. The interactions among these modules aredescribed in detail below.

In some embodiments, the system 101 can communicate with one or moreinput devices 102 through a communication channel. The input device 102generally receives data from a user. The communication channel can be awired connection or through a wireless connection. Examples of acommunication channel include the Internet, a cellular network, or ashort-range wireless network. In some cases, the input device 102 ispart of the system 101. Examples of input devices include, but notlimited to, keyboards, mice, trackball, track pad, joystick, gamecontroller, stylus, sensory environment controllers, remote controller,gaming console, microphones, touchpads, biometric readers, biologicalsignals acquisition apparatus, and sensors. In some embodiments, theinput device is a pointing device including, by way of non-limitingexamples, a mouse. In some embodiments, the input device is a touchscreen or a multi-touch screen. In other embodiments, the input deviceis a microphone to capture voice or other sound input. In otherembodiments, the input device is a video camera or other sensor tocapture motion or visual input. In further embodiments, the input deviceis a Kinect, Leap Motion, or the like. In still further embodiments, theinput device is a combination of devices such as those disclosed herein.

A sensor records actions or sensory signals of a user. Examples ofsensors include, but not limited to, cameras, microphones, positionsensors, RF tags, speed sensors, temperature sensors, liquid sensors,motion sensors, pressure sensors, electric current sensors,electromagnetic sensors, X-ray sensors, light sensors, and electricvoltage sensors. The input device 102 can serve as an interaction toolfor the user interacting with a sensory environment, symptomrepresentation, or symptom alleviation representation enabled by thesystem. Inputs acquired by the input device 102 include, but not limitedto, images, videos, sounds, voices, speech, motion, and biometricsignals. In some embodiments, input signals include symptom descriptionsand/or sensory signals of symptoms. In some embodiments, input signalsare analyzed by a processor to interpret user actions, userinteractions, and user perceptions.

Referring again to FIG. 1, the system can communicate with one or moreoutput devices 105 through a communication channel. The output device105 generally outputs sensory signals that generally stimulate human(animal) senses, such as audio or video signals. The communicationchannel can be a wired connection or through a wireless network. In somecases, the output device 105 is part of the system 101. Examples ofoutput devices include, but not limited to, computer displays,head-mounted virtual reality displays, augmented reality displays,projectors, holographic projectors, speakers, two-dimensional (2-D)printers, three-dimensional (3-D) printers, speech-generating devices,televisions, smartphone, video cards, sound cards, plotters, flatpanels, laser pointers, vest, haptic device, biological signalstimulators, and digital scent generators. An output device 105 maycomprise a display device. In some cases, the output device 105 isintegrated into the system 101. Alternatively, the input device 102 andthe output device 105 are integrated into a single apparatus separatefrom the system 101. For instance, a sensory environment controllercomprises one or more sensors to allow collections of signals related tothe user's actions; on the other hand, the controller comprises a lightsource to project a digital object in the sensory environment.

Referring again to FIG. 1, the system may communicate with one or moreuser devices 110 through a communication channel. The user device 110 istypically an integrated device that includes an input device or anoutput device. The user device 110 generally receives input data from auser or displays output data to a user. The communication channel can bea wired connection or through a wireless network. In some cases, theuser device 110 is part of the system 101, or comprises the system 101.Examples of the user device include, but not limited to, desktopcomputers, smartphones, tablets, and laptops. In some embodiments, theuser device 110 is used by a same user of the system 101. In someinstances, the user device 110 is used by a second user (such as afamily member, or a physician). The user device 110 may be used totransmit additional instructions (e.g., commands on a sensoryenvironment, symptoms or symptom alleviation method) to the system 101,and/or to receive output information (e.g., the sensory environment,digital objects in the sensory environment, and information regardingsymptoms of the user of the device 101) from the system 101.

Referring again to FIG. 1, the system optionally communicates with oneor more servers or devices 120 from a third party through acommunication channel. The communication channel can be a wiredconnection or through a wireless network. Examples of third partiesinclude, but not limited to, hospitals, government agencies, publicinformation providers, banks, news providers, health care providers, andfamily members. In some embodiments, the third party device 120transmits relevant data of the user of the system 101 to the system 101,and the sensory representations created by the system 101 can beadjusted accordingly. In some embodiments, third-party data include, butnot limited to, diagnostic data, vital sign data, neuroimaging data,nociceptor activity data, central nervous activity (CNS) data, heartrate, heart rate variability, galvanic skin response, brain waves, EEGdata, blood pressure, breathing rate, diaphoresis, pupil dilation, eyemovement, temperature, or facial expression data. In some embodimentsthe third party device 120 receives data from the system 101. In someembodiments this data includes, but is not limited to, frequency of useof the system or changes in symptoms.

FIG. 3 describes exemplary steps or operations performed by the systemdisclosed herein. In some embodiments, not all of the operations arerequired. In other embodiments, some of the operations may be performedin a different order. Referring to FIG. 3, in operation 302, the systemcreates a first digital model that represents a context for representinga symptom and the symptom alleviation process. The first digital modelenables generation of a sensory environment comprising first sensorysignals. In some embodiments, the sensory environment comprisesrepresentations of a user or the surroundings. In some cases, thesensory environment comprises objects representing, for example, ascene, a user's avatar, a control panel, an interface, etc. In operation304, the system creates a second digital model for a symptom thatenables generation of second sensory signals and a third digital modelfor alleviation of the symptom that enables generation of third sensorysignals. The sensory representations may comprise visual, audio,tactile, olfactory, or other sensory signals. At least some of thesecond sensory signals and third sensory signals change continuouslyover time to human perception.

In some embodiments, the system can allow a user to customize differentaspects of the digital models based on user input to matchrepresentations of the symptom or the symptom alleviation with theuser's experience or preference. For example, the user can indicate thetype, location, size, shape, frequency, intensity, or other attributesof the symptom (e.g. pain), and the user can indicate the duration,manner, or other aspects of the symptom alleviation. For example, in oneembodiment, the system can allow the user to select from a plurality ofpain types (e.g. aching, throbbing, sore, stabbing, shooting, stabbing,cramping, gnawing, splitting, heavy or burning) and then modify thepain's location, size, intensity, frequency, depth or saturation. Forfurther example, the system allows the user to choose from one of thefollowing symptom alleviation methods: showing the symptom becomingsmaller; reducing in severity or frequency; changing in color orhealing; moving the symptom from one part of the body to another;spreading the symptom from one focal point to a more general area;washing the symptom away with a liquid or gas; cooling or warming theaffected area of the body; moving the symptom into another body orphysical representation (e.g. avatar) separate from the representationof the user (e.g. the user's avatar); creating an augmented experiencein which the user experiences leaving his physical body behind;simulating an out-of-body experience, in which the symptom is leftbehind; improving mobility, motion or function of part or all of thebody.

Further, in operation 306, the system causes output devices generate thefirst, second and third sensory signals (e.g. images, sound, vibration),at least some of which change continuously over time to the user'sperception. In some embodiments, the system sends the first, second, orthird digital models to the output devices and instructs the outputdevices to generate the first, second, or third sensory signals. Thesystem can also cause the output devices to generate sensory signalsthat change continuously over time beyond human perception. The systemcan send the first, second, or third sensory signals to the same outputdevice or different ones, at the same time or at different times,collectively or individually.

In some embodiments, in operation 308, the system analyzes user responseto the sensory signals. The analysis can comprise extracting biometricsignal components from a device (e.g. user device 110, input device 102or third party device 120 in FIG. 1) to understand the behavior orinstructions of the user. In addition, when a user performs an action oran interaction, one or more digital models created by operation 302 or304 may change, and operation 302 or 304 or 306 is executed to modifythe first, second, or third digital models, which lead to updated first,second or third sensory signals. In some cases, new digital models orsensory signals are created, and/or existing digital models or sensorysignals are deleted.

In some embodiments, part or all of the aspects of the digital modelsare saved by means of a digital, electronic or another format. There isno limitation that the related data reside on the system. However,computing modules and data may be hosted on another computationaldevice, such as a wired or wireless computer or server, or in the cloud.

In various embodiments, the systems, methods, media disclosed hereinenable creation of sensory signals that form an immersive experiencebased on virtual reality, augmented reality, holography, etc. FIG. 4illustrates an exemplary presentation of or interaction with a sensoryenvironment. Referring to FIG. 4, a system comprises a digitalprocessing device 401 configured to create a sensory environment 410.The device 401 can be coupled with sensors 402. The sensors 402 trackpositions and/or movements of the user's body, head, hands, fingers,feet, toes, limbs, elbows, lips, eyes, or eyebrows; in some cases, thesensors 402 record sounds, and voices. The user wears a head-mounteddisplay (HMD) 403 to immerse himself into the sensory environment 410displayed in the HMD 403. Further, the user can use a physicalcontroller 404 to make interactions with the sensory environment 410.

In some embodiments, the system 401 creates a model of a user 418. Thesystem 401 can also create a virtual control panel in the sensoryenvironment with which a user can interact to provide control commandsor input data to the system, such as specification of the userrepresentation, a symptom, or a symptom alleviation method. In addition,the system can allow incorporation of forms of sensory signals, such asaudio, into the sensory environment. For example, the system can causethe playing of serene, new-age music in the background. The systemsubsequently causes generation of sensory signals representing symptomsand symptom alleviation within the sensor environment. Such enhancedsensory environment 410 can be powerful in influencing the user, becauseit allows the user to be immersed in a vivid experience of symptomalleviation, which can lead the brain to believe that what is beingseen, heard, or otherwise sensed is real. Further, the sensoryenvironment can be useful in providing an audio-visual stimulus to guideusers towards different perceptions of their pain, physical orpsychological capabilities, or symptoms.

In some embodiments, the sensory environment 410 comprises a 2-D or 3-Davatar 418 representing the user. In some embodiments, the system canallow a user to choose from a list of predetermined avatars or to buildone from scratch. Furthermore, the system can enable the user tocustomize various aspects of the user model, such as size, location,movement, etc. For example, the user can enable changes in the digitalmodels according to time changes. The avatar can display exteriorappearance of the user, and it may additionally include representationsof internal anatomy of the user. In some embodiments, one or more viewsof the user body are displayed, such as a first person point of view, aperspective view, a front view, a side view, a back view, a top view, ora bottom view, simultaneously in different avatars or at different timesas an avatar switches forms. The user is allowed to explore the avatarsfrom different locations, different angles, etc. For example, a user mayprefer that the avatar assumes a first-person view so that the userfeels like looking inside the user's own body and can more vividlyexperience the symptom being driven out of the body.

In some embodiments, the user can sense at least one representation 418of the body in front of the user (corresponding to a mirror image). Therepresentation may represent the user or another person (e.g., a familymember, a patient, a physician, etc.) meaningful to the user. The systemmay also present multiple avatars, including a first one representingthe user and a second one representing a significant other, and allowsthe two avatars to interact. For example, the second avatar can bespeaking to the first avatar or taking the pain away from the firstavatar for symptom alleviation, as further discussed below. The systemmay also present multiple avatars representing different versions of theuser; for example, one with pain, the other without pain. The system mayalso present a non-human representation of or a metaphor for the user.

FIG. 5A illustrates an exemplary user operation to provide a symptomdescription. FIG. 5B illustrates an exemplary user operation to providea further symptom description by managing a digital model of thesymptom. In some embodiments, based on user input, the system createsdigital models of symptoms—such as pain, anxiety, fear, or any otherphysical or psychological manifestations—, digital models of a source ofthe symptoms, or digital models of a metaphor for the symptoms. In somecases, the system can create digital models of the source of or reasonfor (e.g. wound or tissue damage) the symptom (e.g., pain or otherhealth aspect). The system can also allow a user to choose or specifythe nature or form of symptom representation. For example, the nature ofa pain can be aching, throbbing, sore, stabbing, shooting, stabbing,cramping, gnawing, splitting, heavy, burning, etc. The system can createa digital model for the symptom that captures such qualities, forexample, by incorporating an object normally used to produce sucheffects. The symptom can otherwise be represented more abstractly as ared dot, a vicious animal, something that arouses an unpleasant feelingin the user, etc. The system can then allow the user to specify thelocations of the symptom. For example, the system can initially show avirtual representation 508 of a symptom in the sensory environment andthen allow the user using the controller 506 to move that virtualrepresentation to the initial location, such as between the eyes in thehead. The user can work with multiple, different representations of thesame or different symptoms at once. For example, the same symptom can berepresented visually and by audio, and multiple symptoms can be shownvisually in different locations of the avatar.

In some embodiments, the system can allow a user to specify or adjustkey characteristics of a symptom to more accurately reflect the user'sown experience of the symptom. For example, the system can present avirtual cube or coordinate system 503, or some other control console, inthe sensory environment to represent the values (coordinates) of threekey characteristics of a symptom (e.g. frequency, intensity andsaturation), and the user can specify the values of each suchcharacteristic by manipulating a crosshair coordinates tracker 505 inthe virtual cube 503. In response to the user input, the system canadjust the digital model for the symptom and thus the virtualrepresentation of the symptom 501 accordingly. Examples of suchquantifiable or moldable characteristics include, but not limited to asize, duration, frequency, intensity, topography, shape, etc. Forexample, the sensory environment can include a display of a darkerregion to indicate a higher intensity of the symptom and a pulsingeffect to indicate frequency.

In some embodiments, a digital model of a symptom (e.g. pain) may becreated based on one or more templates; alternatively, it can be creatednew by the user (e.g., drawn “free-hand” by the user). The system canprompt or allow a user to provide information regarding the symptom. Theuser can provide textual descriptions, photos, graphical illustrations,sound bites, etc. that characterize the symptom. The user can furtherindicate a source of the symptom, a level of the symptom, and a historyof the symptom. Alternatively, the user can answer a series of questionsor just choose from one of the predetermined templates. The digitalmodels can be dynamic; for example, a representation of a throbbing painwould actually throb continuously in the sensory environment.Furthermore, the digital models can be customized to match the user'sown experience of the symptom; for example, match the frequency andintensity of throbbing pain in the user's own body. In some embodiments,the digital models of symptoms are created or edited by a user or acomputer system (e.g. artificial intelligence or machine learning deviceor a care-giving robot). Furthermore, the digital models can be createdbased on incorporating/uploading an independent file, such as sounds,voices, descriptions, medical history, photos, images, and videos.

FIG. 6 illustrates an exemplary user operation to edit or adjustfeatures of symptom alleviation. In some cases, based on user input, thesystem creates a digital model that represents a treatment oralleviation method. The user is allowed to specify varying parameterssuch as duration, intensity, frequency, manner, or quality associatedwith the method. In FIG. 6, the system causes the display of a virtualpanel 602 in the sensory environment, which allows a user to indicateusing the controller 604 the time it takes for the symptom to disappear,to move to a different location, to assume a substantially differentform, or the time it takes before taking a break, before someone elseintervenes in the process, etc. The same or different user interfacesthat allow the user to describe the symptom can be used to allow theuser to describe the symptom alleviation process.

In some embodiments, the system can provide the user with a list ofsymptom alleviation, reduction, or elimination representations to choosefrom. Example methods include a reduction in size of; an increase of adistance from; an evaporation of; a recoloring/discoloring of; adilution of; a diffusion of; a dissipation of; a relocation of (toanother portion of the user's body, or another location outside theuser's body, including another location within another body); areduction in frequency of; a distortion of; a disappearing of; a washingor blowing away of; a silencing of; a slowing of; a melting of; ahealing of; a stilling; or a cooling of the virtual representation ofthe symptom. The system can allow the user to control specific aspectsof each method. For example, for reduction, the user can be allowed tochange the rate of reduction; for discoloration, the user can be allowedto specify the changing colors. The user can also be allowed to managemultiple symptom alleviation representations at the same time ordifferent times. As one example, the user can request that the systemshow water poured over the symptom representation and if that does notsuffice further show fire burning over the pain representation after aspecific period of time. As another example, the system can show asecond avatar hugging the user's avatar or massaging the shoulder of theuser's avatar or singing a song to the user's avatar, all while theuser's avatar is rubbing the symptom representation. In some cases,these symptom alleviation representations enable the user to have anout-of-body experience, where the user's perception of his bodyself-perception is manipulated such that the user perceives a separationfrom the physical boundaries of the body.

In some embodiments, the representation of symptom alleviation can bemade in a passive, active, or responsive mode, and a user is allowed toselect one or more of these modes. An example of a passive mode can be acase where the user is simply observing a change in symptom development(e.g. watching and meditating on the symptom representation that getssmaller and slower until it disappears). FIG. 7 illustrates an exemplaryrepresentation of symptom improvement, in a passive mode. The user canselect a treatment of a symptom, resulting in the presentation of animprovement, such as a decline, removal, or healing of the symptom orthe cause of the symptom (e.g. wound). Referring to FIG. 7, a symptomrepresentation 701 is shown as a large sphere before any alleviation isapplied; after the alleviation takes effect, the symptom representation702 shrinks. The system automatically and continuously adjusts thesymptom representation towards a smaller size based on a symptomalleviation specification provided by the user earlier without requiringfurther user input.

In an active mode, the user interacts with or “causes” the healingeffect. FIG. 8 illustrates an exemplary representation of symptomalleviation, in an active mode. The user uses a controller in the realworld to actively control the action of pouring water over the symptomrepresentation. The user causes the avatar to pour healing water 801over the symptom representation 803, which is then shown to be washedaway. The system can also show the effect after pouring the healingwater. The purpose of the active mode would be to reinforce the user'ssense of power over the symptom. Over time this sense of empowerment mayhelp change the user's perception of the symptom and/or his relationshipwith the symptom.

Some embodiments include the use of body movement, range of motion orphysical capability or skill. In such embodiments, the user may be askedto make certain movements in the real world, which are represented ormimicked by an avatar in the virtual world. The motion of the avatar maybe more than, less than or the same as the real-world motion of theuser. One example of the use of such techniques is to convince the userthat his or her range of motion is improving or is better thanpreviously perceived. Such information often helps lead to a sense ofempowerment over the symptom (e.g. pain), a reduction in the anxietyabout the symptom and, in some cases, even a reduction in the perceptionof the symptom.

In the responsive mode, the system can use biofeedback, which involvescapturing one or more aspects of the user's own biometric data. Thepurpose of using biofeedback is to allow the user to use the internalbody functions to regulate the virtual representation of symptomalleviation. Such biofeedback can be used to show the user that theuser's physical condition concerning the pain or even other aspects isimproving, and to adjust the pain reduction process. In someembodiments, this technique with the biofeedback signal is not actuallydriving the healing imagery; for example, a sensory representation ofshoulder muscle tension driving neck pain may show a reduction inshoulder tension driving a reduction in neck pain; however, the image ofdeclining muscle tension and pain might not be directly tied to thedecline in actual shoulder tension as measured by the biofeedbackdevice. In other words, the system could vary from traditionalbiofeedback techniques.

Examples of biofeedback include, but not limited to, heart rate, heartrate variability, galvanic skin response, brain waves/EEG data, fMRIdata, blood pressure, breathing rate, diaphoresis, pupil dilation, eyeblinking, eye movement (e.g. saccadic/micro-saccadic movement),temperature, body movement, facial expression data or other data.Biofeedback may also come from a dolorimeter or similar devices tomeasure pain or calculate a correlation with pain. The biofeedback datamay be augmented with other data derived from the hardware and softwareinstantiating the virtual environment (e.g., a virtual reality headmounted display). There are many advantages by integrating biofeedbackinformation. Biofeedback can be used to regulate body functions, whichhave direct or indirect bearing on the experience of pain; for example,certain types of chronic neck pain increase with tension in theshoulders. If biofeedback can be used to train the user to relax, theuser may actually experience less pain in the real body, as well asseeing a reduction in pain in the virtual body (the avatar in thevirtual environment).

In some embodiments, the system allows the user to control variousaspects of the utilizing biofeedback. For example, the user can specifywhere to collect biofeedback, how often and for how long biofeedback isto be collected, what types of biofeedback is to be collected, how thebiofeedback is to be used or presented, etc. In some embodiments, thesystem can infer a user's health condition and/or asks the user toprovide direct feedback on a level of pain, discomfort, or psychologicalstate. The feedback can be solicited before, during and after the user'sexperience of symptom alleviation provided by the system. In someembodiments, a user can provide feedback upon the system request, orwhenever the user wishes. In some embodiments, the feedback is notsupplied by the user, but is automatically collected before, during orafter symptom alleviation by examination of all or part of the user'sbody. Furthermore, as discussed above, the system can enable a user tovisualize or otherwise sense the collected biofeedback directly and/oruse it to adjust the symptom or the symptom alleviation process.

An example of the use of heart rate biofeedback is as follows. Alongwith the representation of the user's pain, the system provides arepresentation of the user's heart rate. As the user feels pain, his orher heart rate tends to rise. Lowering heart rate may help the personrelax and in some cases this leads to a reduction in pain. When the usermanages to lower the heart rate into a target range, the representationof the pain starts to improve—e.g. decline, dissipate, or “heal.” Inother words, the system can incorporate biofeedback techniques toprovide the user with a way to drive the healing and obtain physicalevidence of body condition improvement, while at the same time givingthe user physiological training which can help the user reduce sensorypain.

FIG. 9 illustrates an exemplary representation of a symptom withdifferent types of sensory signals. In this case, the symptom is athrobbing pain. The haptic vest 901 is configured to vibrate at the samefrequency as the throbbing. On the other hand, the system allows theuser to further draw a throbbing back pain and choose a healingmethodology in which the symptom representation gets smaller anddissipates. The system further causes display of visual signals, such asdynamic images of lightning bolts 903, to represent the throbbing natureand indicate healing in progress through the decreasing intensity of thelightning bolts. As a result, the vibration in the tactile vest 901which corresponds to the throbbing pain also gets softer and slower. Inthis manner, the system allows the user to simultaneously experience twotypes of sensory stimulation through both visual and hapticrepresentations of the throbbing, which may increase the therapeuticeffect.

In some embodiments, the creation of the digital model of the symptom orsymptom alleviation can be accompanied by audio-visual or othermultimedia guidance, such as a guided protocol or instructions, guidedmeditation, or affirmations. In some embodiments, the audio-visualguidance is used to reinforce a user's sense of empowerment to controlthe user's symptom. In some embodiments, the multimedia guidance is usedto train or reinforce symptom handling techniques, such as cognitivebehavioral therapy or specific instructions from a helper (e.g.physician, psychologist). The audio-visual guidance may compriserecordings of the user's own thoughts (e.g. self-affirmations of thepatient's ability to control the pain), for example.

Complementary Devices

In various embodiments, the system may comprise other equipment ordevices, or use of the same. The other devices, including user devices,sensors, input devices, output devices, or integrated electronicdevices, can be coupled with the system to augment the experience ofsymptoms or symptom alleviation.

In some embodiments, the system comprises or communicates with equipmentto provide the user with audio-visual entrainment (AVE) signals orbinaural beats. It is possible to modify the brain waves within a human(or animal) with the use of visual or audio signals at specificfrequencies. Binaural beats is one example of AVE. A binaural beat is anauditory illusion of a third tone perceived when two different pure-tonesine waves, both with frequencies under 1500 Hz where the difference infrequency is less than a 40 Hz, are provided to a listener, one througheach ear. Binaural beats can be used to synchronize brain waves toexternally induced signals. Applications may be varied and includeinducing a more relaxed state, modulating heart rate variability, etc.The use of AVE may make humans more open to suggestion. In someembodiments, AVE is a useful tool to augment the effect of thetechnologies—e.g. relaxing the patient to help reduce the experience ofpain.

In some embodiments, the system comprises or communicates with equipmentto provide tactile or haptic experience in the user, such as avibration, throbbing, poking. Such a device can be used to augment thepower of the illusion of the virtual symptom (e.g. pain) in the virtualenvironment. For example, a haptic vest in FIG. 9 could vibrate at thesame frequency as a throbbing pain drawn in the avatar. During the“healing” process that haptic input could become softer or less intenseto match the visual and audio representation of a throbbing pain goingaway. Tactile/haptic devices are also powerful tools in inducing anout-of-body experience.

In some embodiments, the system comprises or communicates with aheating/cooling device. Similar to haptic devices, the heating/coolingdevices are used to enhance the sensation of healing effects. Forexample, a cooling device can augment a healing method where a burningpain is cooled down.

In some embodiments, the system comprises or communicates with a musclestimulator, a nerve stimulator, a transcutaneous electrical nervestimulator (TENS), and/or a muscle relaxer. These devices may beexternal or implanted devices incorporated into some embodimentsdisclosed herein. Some such devices can be used to help stimulate orrelax specific areas of the body to mimic/augment either the symptom(e.g. pain) or healing of the symptom. Some devices can also be used toinduce a physical effect in a nerve or muscle that helps create aphysical reduction in the symptom (e.g. pain) while the invention helpsto drive the psychological factor in the perception of (reduced) pain.For example, certain muscle and nerve stimulators induce a temporaryquieting of peripheral nerves, which can create a physical reduction insensory pain signals to the brain at a time when the invention creates apsychological perception of pain healing effect.

In some embodiments, the system comprises or communicates with a brainor nervous system stimulating device. The brain stimulating device, suchas a transcranial direct current stimulation (TDCS) device, atranscranial magnetic stimulations (TMS) device or a spinal cordstimulator, can be added to various embodiments. The application of suchan addition varies. One use of TDCS and TMS is to send magnetic wavesinto the brain, which have shown the ability to reduce sensations ofpain. Another use of such a device may be to increase neuroplasticity ofthe brain.

In some embodiments, the system comprises or communicates with anolfactory device. The olfactory device (e.g. fragrances or smells) canbe used to create mood or mental state in a user, thus augmenting theexperience. In addition, smell can be a powerful trigger for memories,and thus can become an important anchor or trigger of the healingsensation. For example, a symptom relieving action is performed by theuser by interacting with a representation of a symptom, and the systemtriggers an olfactory device to emit nice smells to relax the user'smood.

In some embodiments, the system comprises or communicates with otherintegrated computing devices, which include combines one or more of thetypes of devices discussed above.

Complementary Therapies

In some embodiments, the system is used in combination with prescriptionand/or non-prescription pharmacological therapies involving the use ofvarious chemical compounds (e.g., drugs pharmaceuticals, vitamins,minerals, etc.). A compound might include agents, which have ananalgesic effect, inhibit pain signals, induce relaxation, reduceanxiety, or create a mental state that is more beneficial forneuroplasticity or rewiring.

Digital Processing Devices

In some embodiments, the system described herein includes a digitalprocessing device, or use of the same. In further embodiments, thedigital processing device includes one or more hardware centralprocessing units (CPUs) or general purpose graphics processing units(GPGPUs) that carry out the device's functions. The digital processingdevice may include substantial computational and storage capability,such as a database, an array of rules or algorithms or artificialintelligence (AI), to control the audio-visual or similar content. Thedigital processing device can perform part or all of the data processingand analysis typically performed by the system. In some embodiments, thedigital processing device is optionally connected to a computer network.In other embodiments, the digital processing device is optionallyconnected to a data storage device.

In accordance with the description herein, suitable digital processingdevices include, by way of non-limiting examples, desktop computers,laptop computers, notebook computers, sub-notebook computers, netbookcomputers, net pad computers, set-top computers, and media streamingdevices, handheld computers, Internet appliances, mobile smartphones,tablet computers, personal digital assistants, video game consoles, andvehicles. The digital processing device can also be implemented as asever farm, a parallel computing device, a cloud-computing platform,etc. Those of skill in the art will recognize that many smartphones aresuitable for use in the system described herein. Those of skill in theart will also recognize that select televisions, video players, anddigital music players with optional computer network connectivity aresuitable for use in the system described herein. Suitable tabletcomputers include those with booklet, slate, and convertibleconfigurations, known to those of skill in the art.

In some embodiments, the device includes a storage and/or memory device.The storage and/or memory device is one or more physical apparatusesused to store data or programs on a temporary or permanent basis. Insome embodiments, the device is volatile memory and requires power tomaintain stored information. In some embodiments, the device isnon-volatile memory and retains stored information when the digitalprocessing device is not powered. In further embodiments, thenon-volatile memory comprises flash memory. In some embodiments, thenon-volatile memory comprises dynamic random-access memory (DRAM). Insome embodiments, the non-volatile memory comprises ferroelectric randomaccess memory (FRAM). In some embodiments, the non-volatile memorycomprises phase-change random access memory (PRAM). In otherembodiments, the device is a storage device including, by way ofnon-limiting examples, CD-ROMs, DVDs, flash memory devices, magneticdisk drives, magnetic tapes drives, optical disk drives, and cloudcomputing based storage. In further embodiments, the storage and/ormemory device is a combination of devices such as those disclosedherein.

In some embodiments, the digital processing device includes a display tosend visual information to a user. In some embodiments, the display is acathode ray tube (CRT). In some embodiments, the display is a liquidcrystal display (LCD). In further embodiments, the display is a thinfilm transistor liquid crystal display (TFT-LCD). In some embodiments,the display is an organic light emitting diode (OLED) display. Invarious further embodiments, on OLED display is a passive-matrix OLED(PMOLED) or active-matrix OLED (AMOLED) display. In some embodiments,the display is a plasma display. In other embodiments, the display is avideo projector. In still further embodiments, the display is acombination of devices such as those disclosed herein.

FIG. 10 illustrates an exemplary computing architecture applicable toany computing device discussed herein. In some embodiments, the digitalprocessing device 1001 includes a central processing unit (CPU, also“processor” and “computer processor” herein) 1005, which can be a singlecore or multi core processor, or a plurality of processors for parallelprocessing. The digital processing device 1001 also includes memory ormemory location 1010 (e.g., random-access memory, read-only memory,flash memory), electronic storage unit 1015 (e.g., hard disk),communication interface 1020 (e.g., network adapter) for communicatingwith one or more other systems, and peripheral devices 1025, such ascache, other memory, data storage and/or electronic display adapters.The memory 1010, storage unit 1015, interface 1020 and peripheraldevices 1025 are in communication with the CPU 1005 through acommunication bus (solid lines), such as a motherboard. The outputs canbe shown on a display 1035. The storage unit 1015 can be a data storageunit (or data repository) for storing data. The digital processingdevice 1001 can be operatively coupled to a computer network (“network”)1030 with the aid of the communication interface 1020. The network 1030can be the Internet, an internet and/or extranet, or an intranet and/orextranet that is in communication with the Internet. The network 1030 insome cases is a telecommunication and/or data network. The network 1030can include one or more computer servers, which can enable distributedcomputing, such as cloud computing. The network 1030, in some cases withthe aid of the device 1001, can implement a peer-to-peer network, whichmay enable devices coupled to the device 1001 to behave as a client or aserver.

Continuing to refer to FIG. 10, the CPU 1005 can execute a sequence ofmachine-readable instructions, which can be embodied in a program orsoftware. The instructions may be stored in a memory location, such asthe memory 1010. The instructions can be directed to the CPU 1005, whichcan subsequently program or otherwise configure the CPU 1005 toimplement methods of the present disclosure. Examples of operationsperformed by the CPU 1005 can include fetch, decode, execute, and writeback. The CPU 1005 can be part of a circuit, such as an integratedcircuit. One or more other components of the device 1001 can be includedin the circuit. In some cases, the circuit is an application specificintegrated circuit (ASIC) or a field programmable gate array (FPGA).

Continuing to refer to FIG. 10, the storage unit 1015 can store files,such as drivers, libraries and saved programs. The storage unit 1015 canstore user data, e.g., user preferences and user programs. The digitalprocessing device 1001 in some cases can include one or more additionaldata storage units that are external, such as located on a remote serverthat is in communication through an intranet or the Internet.

Continuing to refer to FIG. 10, the digital processing device 1001 cancommunicate with one or more remote computer systems through the network1030. For instance, the device 1001 can communicate with a remotecomputer system of a user. Examples of remote computer systems includepersonal computers (e.g., portable PC), slate or tablet PCs (e.g.,Apple® iPad, Samsung® Galaxy Tab), telephones, Smart phones (e.g.,Apple® iPhone, Android-enabled device, Blackberry®), or personal digitalassistants.

Methods as described herein can be implemented by way of machine (e.g.,computer processor) executable code stored on an electronic storagelocation of the digital processing device 1001, such as, for example, onthe memory 1010 or electronic storage unit 1015. The machine executableor machine readable code can be provided in the form of software. Duringuse, the code can be executed by the processor 1005. In some cases, thecode can be retrieved from the storage unit 1015 and stored on thememory 1010 for ready access by the processor 1005. In some situations,the electronic storage unit 1015 can be precluded, andmachine-executable instructions are stored on memory 1010.

Computer Program

In various embodiments, the systems, methods, media disclosed hereininclude a computer program, or use of the same. The computer programproduct is embodied in a non-transitory computer-readable medium, thecomputer program product comprising instructions adapted to effectuatethe method above. The technologies can be in the form of a video game,software application, app or software code (or similar electronic means)that can be implemented on a virtual reality, augmented reality,holographic or other electronic device (e.g., tablet or smartphone).

In some embodiments, the platforms, systems, media, and methodsdisclosed herein include at least one computer program, or use of thesame. A computer program includes a sequence of instructions, executablein the digital processing device's CPU, written to perform a specifiedtask. Computer readable instructions may be implemented as programmodules, such as functions, objects, Application Programming Interfaces(APIs), data structures, and the like, that perform particular tasks orimplement particular abstract data types. In light of the disclosureprovided herein, those of skill in the art will recognize that acomputer program may be written in various versions of variouslanguages, and may incorporate or make use of pre-existing softwareprogramming or game development software.

The functionality of the computer readable instructions may be combinedor distributed as desired in various environments. In some embodiments,a computer program comprises one sequence of instructions. In someembodiments, a computer program comprises a plurality of sequences ofinstructions. In some embodiments, a computer program is provided fromone location. In other embodiments, a computer program is provided froma plurality of locations. In various embodiments, a computer programincludes one or more software modules. In various embodiments, acomputer program includes, in part or in whole, one or more webapplications, one or more mobile applications, one or more standaloneapplications, one or more web browser plug-ins, extensions, add-ins, oradd-ons, or combinations thereof.

Non-Transitory Computer Readable Storage Medium

In some embodiments, the platforms, systems, media, and methodsdisclosed herein include one or more non-transitory computer readablestorage media encoded with a program including instructions executableby the operating system of an optionally networked digital processingdevice. In further embodiments, a computer readable storage medium is atangible component of a digital processing device. In still furtherembodiments, a computer readable storage medium is optionally removablefrom a digital processing device. In some embodiments, a computerreadable storage medium includes, by way of non-limiting examples,CD-ROMs, DVDs, flash memory devices, solid state memory, magnetic diskdrives, magnetic tape drives, optical disk drives, cloud computingsystems and services, and the like. In some cases, the program andinstructions are permanently, substantially permanently,semi-permanently, or non-transitorily encoded on the media.

Software Modules

In some embodiments, the platforms, systems, media, and methodsdisclosed herein include software, server, and/or database modules, oruse of the same. In view of the disclosure provided herein, softwaremodules are created by techniques known to those of skill in the artusing machines, software, and languages known to the art. The softwaremodules disclosed herein are implemented in a multitude of ways. Invarious embodiments, a software module comprises a file, a section ofcode, a programming object, a programming structure, or combinationsthereof. In further various embodiments, a software module comprises aplurality of files, a plurality of sections of code, a plurality ofprogramming objects, a plurality of programming structures, orcombinations thereof. In various embodiments, the one or more softwaremodules comprise, by way of non-limiting examples, a web application, amobile application, and a standalone application. In some embodiments,software modules are in one computer program or application. In otherembodiments, software modules are in more than one computer program orapplication. In some embodiments, software modules are hosted on onemachine. In other embodiments, software modules are hosted on more thanone machine. In further embodiments, software modules are hosted oncloud computing platforms. In some embodiments, software modules arehosted on one or more machines in one location. In other embodiments,software modules are hosted on one or more machines in more than onelocation.

Databases

In some embodiments, the platforms, systems, media, and methodsdisclosed herein include one or more databases, or use of the same. Inview of the disclosure provided herein, those of skill in the art willrecognize that many databases are suitable for storage and retrieval ofrecorded information (e.g. pain or symptom information). In variousembodiments, suitable databases include, by way of non-limitingexamples, relational databases, non-relational databases, objectoriented databases, object databases, entity-relationship modeldatabases, associative databases, and XML, databases. In someembodiments, a database is internet-based. In further embodiments, adatabase is web-based. In still further embodiments, a database is cloudcomputing-based. In other embodiments, a database is based on one ormore local computer storage devices.

While preferred embodiments of the present invention have been shown anddescribed herein, it will be obvious to those skilled in the art thatsuch embodiments are provided by way of example only. Numerousvariations, changes, and substitutions will now occur to those skilledin the art without departing from the invention. It should be understoodthat various alternatives to the embodiments of the invention describedherein may be employed in practicing the invention. It is intended thatthe following claims define the scope of the invention and that methodsand structures within the scope of these claims and their equivalents becovered thereby.

Preferred embodiments include a method of representing symptoms andsymptoms alleviation, comprising: creating, by one or more processors, afirst digital model for generating a sensory environment comprisingfirst sensory signals; causing an output device to execute the firstdigital model to generate the sensory environment; creating a seconddigital model for a symptom, wherein the second digital model causesgeneration of second sensory signals; causing the output device togenerate the second sensory signals within the sensory environment basedon the second digital model; creating a third digital model of analleviation or removal of the symptom based on the first or the seconddigital models, wherein the third digital model causes generation ofthird sensory signals, and wherein at least a portion of the secondsensory signals and/or third sensory signals change continuously overtime to human perception; and causing the output device to generate thethird sensory signals within the sensory environment based on the thirddigital model.

Numbered paragraphs corresponding to inventive concepts:

In combination with any aforementioned methods in this disclosure, thefirst, second, or third digital model is a two-dimensional orthree-dimensional model.

In combination with any aforementioned methods in this disclosure, theoutput device comprises multiple devices and the first sensory signals,second sensory signals, and third sensory signals are individually orcollectively sent to one or more of the multiple devices.

In combination with any aforementioned methods in this disclosure, thefirst sensory signals, second sensory signals, or third sensory signalsform holographic, virtual-reality, or augmented-reality representations.

In combination with any aforementioned methods in this disclosure, thefirst, second, or third output device produces audio, visual, tactile orolfactory signals.

In combination with any aforementioned methods in this disclosure, thefirst sensory signals, second sensory signals, or third sensory signalsare produced responsive to user input.

In combination with any aforementioned methods in this disclosure, themethod further comprises receiving a description of the symptom, whereincreating the second digital model is based on the description.

In combination with any aforementioned methods in this disclosure, thedescription of the symptom comprises an illustration of the symptom.

In combination with any aforementioned methods in this disclosure, thedescription of the symptom comprises one or more of a photo, a video, ananimation, a sound, a vibration, or a scent.

In combination with any aforementioned methods in this disclosure, theillustration includes a representation of a wound or tissue damage thatcaused the symptom.

In combination with any aforementioned methods in this disclosure, thedescription of the symptom comprises scores for one or more a predefinedset of symptom characteristics.

In combination with any aforementioned methods in this disclosure, thedescription is for various pain types, including one or more of aching,throbbing, sore, stabbing, shooting, stabbing, cramping, gnawing,splitting, heavy, or burning.

In combination with any aforementioned methods in this disclosure,creating the second digital model comprises: acquiring one of aplurality of template models for the symptom; and personalizing thetemplate model based on the description.

In combination with any aforementioned methods in this disclosure, theone template model corresponds to a physical quality of the symptom.

In combination with any aforementioned methods in this disclosure,further comprising receiving a selection from the plurality of templatemodels, wherein the acquiring is based on the selection.

In combination with any aforementioned methods in this disclosure, theplurality of template models is associated with a symptom type orlocation.

In combination with any aforementioned methods in this disclosure, thesensory environment includes a user interface for providing adescription of the symptom or selecting from a set of predefineddescriptions.

In combination with any aforementioned methods in this disclosure, theuser interface comprises illustration tools corresponding to apredefined set of symptom characteristics.

In combination with any aforementioned methods in this disclosure, thesecond digital model is modified to represent changes in qualities ofthe symptom, including, without limitation, duration, intensity,frequency, depth, topography, sharpness, or appearance.

In combination with any aforementioned methods in this disclosure, theuser interface is configured to prompt a user to provide the descriptionof the symptom.

In combination with any aforementioned methods in this disclosure, theprompting comprises presenting a prompt for localizing the symptom on abody of the user.

In combination with any aforementioned methods in this disclosure, theprompting comprises presenting prompts corresponding to a location ofthe symptom, a size of the symptom or a set of predefined symptomcharacteristics or qualities.

In combination with any aforementioned methods in this disclosure, themethod further comprises modifying the second digital model responsiveto user input.

In combination with any aforementioned methods in this disclosure, themethod further comprising: receiving current diagnostic data for a userincluding vital sign data, neuroimaging data, nociceptor activity data,or central nervous activity (CNS) data; and modifying the second digitalmodel based on the current diagnostic data.

In combination with any aforementioned methods in this disclosure, vitalsign data includes heart rate, heart rate variability, galvanic skinresponse, brain waves, EEG data, blood pressure, breathing rate,diaphoresis, pupil dilation, eye movement, temperature, or facialexpression data.

In combination with any aforementioned methods in this disclosure, thesensory environment includes an avatar of a user.

In combination with any aforementioned methods in this disclosure, theavatar represents a body of the user.

In combination with any aforementioned methods in this disclosure, aview of the avatar corresponds to a first-person view or a third-personview for the user.

In combination with any aforementioned methods in this disclosure, thethird-person view is a perspective view, a front view, a side view, aback view, a top view, or a bottom view.

In combination with any aforementioned methods in this disclosure, theview of the avatar switches between the first- and third-person views.

In combination with any aforementioned methods in this disclosure, themethod further comprises modifying the first digital model to generate achange to the avatar responsive to user input.

In combination with any aforementioned methods in this disclosure, thechange is in a position, size, or appearance of the avatar.

In combination with any aforementioned methods in this disclosure, thesecond or third sensory signals are generated on or within the avatar.

In combination with any aforementioned methods in this disclosure, thefirst sensory signals are generated in accordance with a localization ofthe symptom.

In combination with any aforementioned methods in this disclosure,generation of the third sensory signals comprises a passive animation ofthe symptom.

In combination with any aforementioned methods in this disclosure, themethod further comprises determining a symptom alleviation method,wherein creation of the third digital model is based on the symptomalleviation method.

In combination with any aforementioned methods in this disclosure, thesymptom alleviation method includes parameters comprising a duration,intensity, manner, or quality of symptom alleviation.

In combination with any aforementioned methods in this disclosure, thethird digital model corresponds to one or more of: a reduction in sizeof; an increase of a distance from; an evaporation of; arecoloring/discoloration of; a dilution of; a diffusion of; adissipation of; a relocation of; a reduction in frequency of; adistortion of; a disappearing of; a washing or blowing away of; aremoval of; a throwing away of; a silencing of; a slowing of; a meltingof; a healing of; a stilling of; or a cooling of the symptom.

In combination with any aforementioned methods in this disclosure, thethird digital model corresponds to creating a set of stimuli, whichleads the user to experience changes in body self-perception or anout-of-body experience.

In combination with any aforementioned methods in this disclosure, thesymptom is real or imagined.

In combination with any aforementioned methods in this disclosure, thesymptom corresponds to a missing limb.

In combination with any aforementioned methods in this disclosure, thesymptom comprises a chronic symptom, an acute symptom, a visceralsymptom, or a neuropathic symptom.

In combination with any aforementioned methods in this disclosure, thesymptom corresponds to a current physical injury or emotional sufferingof a user.

In combination with any aforementioned methods in this disclosure, themethod further comprises directing a device to physically stimulate auser while the user is being presented with the sensory environment.

In combination with any aforementioned methods in this disclosure, themethod further comprises directing a device to stimulate a muscle of theuser while being presented with the sensory environment, wherein themuscle is related to a localization of the symptom or is a trigger foror a factor in experiencing the symptom.

In combination with any aforementioned methods in this disclosure,further comprises directing a device to stimulate an area of a brain ofa user while the user is being presented with the sensory environment,wherein the area of the brain is related to the localization of thesymptom, a physical, cognitive or emotional experience of the symptom bythe user, or a control of the symptom by the user.

In combination with any aforementioned methods in this disclosure, themethod further comprises directing a device to entrain a user whilebeing presented with the virtual environment.

In combination with any aforementioned methods in this disclosure, themethod further comprises applying a relaxation technique while thepatient is being presented with the virtual environment.

In combination with any aforementioned methods in this disclosure, themethod further comprises: determining a first symptom response of a userat a first time; determining a second symptom response of the user at asecond time; and determining a change in an experience of the symptom bythe user by comparing the first symptom response and the second symptomresponse.

In combination with any aforementioned methods in this disclosure,determining the first or the second symptom response is based on userinput or a scan of a target portion of a body of the user.

In combination with any aforementioned methods in this disclosure, thetarget portion of the body of the user comprises nociceptors or thecentral nervous system (CNS) or a brain of the user.

In combination with any aforementioned methods in this disclosure, thefirst time is before the user is presented with the first sensorysignals, the second sensory signals or the third sensory signals, andthe second time is afterwards.

In combination with any aforementioned methods in this disclosure, themethod further comprise: monitoring vital sign data or biometric data ofa user; and modifying the second and third digital models responsive toa change in the vital sign or biometric data.

In combination with any aforementioned methods in this disclosure, themethod further comprises: generating, before a user is presented withthe first sensory signals, the second sensory signals or the thirdsensory signals, a first map of a range of motion, a strength test, oran endurance test of the user; generating, after the user is presentedwith the first sensory signals, the second sensory signals or the thirdsensory signals, a second map of the range of motion, strength test, orendurance test; and determining a change in an experience of the symptomby the user based on comparing the first map and second map.

In combination with any aforementioned methods in this disclosure, themethod further comprises sending the first, second, or third digitalmodel to a remote device over a communication network.

In combination with any aforementioned methods in this disclosure, themethod further comprises receiving a specification of a symptomalleviation method; generating a simplified version of the first,second, or third digital model, and sending the specification and thesimplified version to a remote device over a communication network.

In combination with any aforementioned methods in this disclosure, thethird sensory signals creates a sensation within the user of the mind orconsciousness of the user leaving the user's body and floating above orbeside the user's body, the mind or consciousness moving from one bodyto another, a part of the body leaving the main body, or one or moresymptoms leaving the body.

Preferred embodiments, alone or in combination with any aforementionedmethods in this disclosure, include a method of representing symptomalleviation, comprising receiving information regarding alleviating asymptom, including a selection from a plurality of predetermined modesfor representing symptom alleviation; generating a digital model foralleviating the symptom based on the received information; and managinga symptom alleviation experience based on the received information.

In combination with any aforementioned methods in this disclosure, theplurality of predetermined modes includes a passive mode, an activemode, and a responsive mode, wherein when the selection is the passivemode, the managing includes sending the digital model to an outputdevice and causing the output device to generate sensory signals basedon the digital model, wherein when the selection is the active mode, themanaging includes receiving user instructions from an input device, andwherein when the selection is the responsive mode, the managing includesreceiving biometric data from a sensor device.

In combination with any aforementioned methods in this disclosure, whenthe selection is the active or responsive mode, the managing furtherincludes updating the digital mode based on the user instructions or thebiometric data.

In combination with any aforementioned methods in this disclosure, whenthe selection is the active or responsive mode, the managing furtherincludes updating the digital model based on the user instructions oruser biofeedback.

In combination with any aforementioned methods in this disclosure, thebiofeedback includes a heart rate, heart rate variability, breathing,galvanic skin response, brain waves, EEG signals, fMRI signals, ormuscle tension.

In combination with any aforementioned methods in this disclosure, thethird digital model includes verbal or visual teachings for the user,including, without limitation, skills for coping with the symptom oraffirmations on the user's power to control or alleviate the symptom.

In combination with any aforementioned methods in this disclosure, themethod further comprises receiving a specification of a symptomalleviation method; generating a simplified version of the first,second, or third digital model, and sending the specification and thesimplified version to a remote device over a communication network.

Preferred embodiments, alone or in combination with any aforementionedmethods in this disclosure, include a system for representing symptomsand symptom alleviation, comprising: a processor; and a memoryoperatively coupled to the processor and configured for storing datainstructions that, when executed by the processor, cause the system toperform a method, the method comprising: creating a first digital modelfor generating a sensory environment comprising first sensory signals;causing an output device to execute the first digital model to generatethe sensory environment; creating a second digital model for a symptom,wherein the second digital model causes generation of second sensorysignals; causing the output device to generate the second sensorysignals within the sensory environment based on the second digitalmodel; creating a third digital model of an alleviation or removal ofthe symptom based on the first or the second digital models, wherein thethird digital model causes generation of third sensory signals, andwherein at least a portion of the second sensory signals and/or thirdsensory signals change continuously over time to human perception; andcausing the output device to generate the third sensory signals withinthe sensory environment based on the third digital model.

In combination with any aforementioned systems in this disclosure, thefirst, second, or third device is a head mounted virtual realitydisplay, and augmented reality display, monitor, speaker, haptic device,holographic display, smart wearable device, or a smart handheld device.

In combination with any aforementioned systems in this disclosure, themethod further comprises directing a stimulating device to physicallystimulate a user while the user is being presented with the sensoryenvironment.

In combination with any aforementioned systems in this disclosure, thestimulating device is a muscle-stimulating device or a brain-stimulatingdevice.

Preferred embodiments, alone or in combination with any aforementionedmethods or systems in this disclosure, include a non-transitorycomputer-readable storage medium with instructions stored thereon that,when executed by a processor, cause the processor to perform a method ofrepresenting symptoms and symptom alleviation, the method comprising:creating, by one or more processors, a first digital model forgenerating a sensory environment comprising first sensory signals;causing an output device to execute the first digital model to generatethe sensory environment; creating a second digital model for a symptom,wherein the second digital model causes generation of second sensorysignals; causing the output device to generate the second sensorysignals within the sensory environment based on the second digitalmodel; creating a third digital model of an alleviation or removal ofthe symptom based on the first or the second digital models, wherein thethird digital model causes generation of third sensory signals, andwherein at least a portion of the second sensory signals and/or thirdsensory signals change continuously over time to human perception; andcausing the output device to generate the third sensory signals withinthe sensory environment based on the third digital model.

What is claimed is:
 1. A system for modeling a symptom of a user,comprising: a display system; a sensory device configured to produce oneor more of audio, tactile, or olfactory signals; and a computer systemcommunicatively coupled with the display system and the sensory device,the computer system comprising: one or more processors; and one or morecomputer-readable storage media having stored thereoncomputer-executable instructions that, when executed by the one or moreprocessors, configure the computer system to create a multidimensionalsensory environment comprising a digital model and sensory signalsassociated with a symptom of a user by causing the computer system toperform at least the following: cause the display system to produce afirst digital model within the multidimensional sensory environment, thefirst digital model comprising a representation of one or more of aroom, a landscape, an avatar, or a control panel; receive a descriptionof the symptom, comprising visual sensory signals and aural, tactile, orolfactory signals associated with the symptom; receive keycharacteristics of the symptom, comprising values associated with thevisual, aural, tactile, and/or olfactory signals associated with thesymptom; based on the description and the key characteristics, generatea second digital model of the symptom comprising ci) a set of visualsensory signals and (ii) a set of aural, tactile, or olfactory signals;cause the display system to produce the set of visual sensory signalsassociated with the second digital model at a location within themultidimensional sensory environment; and cause the sensory device tooutput the set of aural, tactile, or olfactory signals associated withthe second digital model, wherein the second digital model is customizedto match the set of audio, tactile, or olfactory signals with the set ofvisual sensory signals associated with the symptom, as informed by thedescription and the key characteristics of the symptom.
 2. The system ofclaim 1, wherein the second digital model reflects a visualinstantiation of the user's own experience of the symptom.
 3. The systemof claim 1, wherein the display system comprises a holographic projectoror display and the set of visual sensory signals comprises holographicprojections or displays of the first digital model.
 4. The system ofclaim 1, wherein the display system is configured to produce one or moreof augmented reality, virtual reality, or mixed reality display orprojection of the first digital model.
 5. The system of claim 4, whereinthe display system comprises a head mounted display.
 6. The system ofclaim 1, wherein the set of aural, tactile, or olfactory signalsassociated with the second digital model reflects an aural, tactile, orolfactory instantiation of the user's own experience of the symptom. 7.The system of claim 6, wherein the sensory device comprises a hapticdevice and the set of aural, tactile, or olfactory signals associatedwith the second digital model comprises a set of aural or tactilesignals configured to be implemented by the haptic device.
 8. The systemof claim 7, wherein causing the sensory device to output the set ofaural or tactile signals associated with the second digital modelcomprises causing the haptic device to produce the set of haptic oraural signals associated with the symptom.
 9. The system of claim 7,wherein the haptic device comprises a smart wearable device, a smarthand-held device, or a haptic vest.
 10. The system of claim 7, whereinthe computer-executable instructions, when executed by the one or moreprocessors, further cause the computer system to modulate at least oneof the values associated with the set of tactile signals, the valuescomprising one or more of an intensity, a location, or a frequency ofthe set of tactile signals.
 11. The system of claim 10, wherein theintensity, the location, or the frequency of the set of tactile signalsis modulated to correspond with a third digital model representing achange over time to human perception in at least a portion of the set oftactile signals.
 12. The system of claim 11, wherein the third digitalmodel comprises a representation of symptom alleviation.
 13. The systemof claim 11, wherein the intensity, the location, or the frequency ofthe set of tactile signals is modulated to correspond with data receivedfrom a biofeedback device.
 14. The system of claim 6, wherein thesensory device comprises an olfactory device and the set of aural,tactile, or olfactory signals associated with the second digital modelcomprises a set of olfactory signals configured to be implemented by theolfactory device.
 15. The system of claim 14, wherein thecomputer-executable instructions, when executed by the one or moreprocessors, further cause the computer system to modulate at least oneof the values associated with the set of olfactory signals, the valuescomprising one or more of an intensity, a duration, or a fragrance ofthe set of olfactory signals to correspond with a third digital modelrepresenting symptom alleviation.
 16. A computer program productcomprising one or more computer-readable hardware storage devices havingstored thereon one or more computer-executable instructions that areexecutable by one or more processors of a computer system to cause thecomputer system to create a multidimensional sensory environmentcomprising a digital model and sensory signals associated with a symptomof a user by causing the computer system to perform at least thefollowing: cause a display system communicatively coupled to thecomputer system to produce a first digital model within themultidimensional sensory environment, the first digital model comprisinga representation of one or more of a room, a landscape, an avatar, or acontrol panel; receive a description of the symptom, comprising visualsensory signals and aural, tactile, or olfactory signals reflecting auser's own experience of the symptom; receive key characteristics of asymptom, comprising values associated with the visual, aural, tactile,and/or olfactory signals reflecting a user's own experience of thesymptom; generate a second digital model of the symptom based on thedescription and the key characteristics, the second digital modelcomprising (i) a set of visual sensory signals and (ii) a set of aural,tactile, or olfactory signals associated with the symptom; cause thedisplay system to produce the set of visual sensory signals associatedwith the second digital model at a location within the multidimensionalsensory environment; and cause a sensory device to output the set ofaural, tactile, or olfactory signals associated with the second digitalmodel, wherein the second digital model is customized to match the setof audio, tactile, or olfactory signals with the set of visual sensorysignals associated with the symptom, as informed by the description andthe key characteristics of the symptom.
 17. The computer program productof claim 16, wherein causing the display system to produce the seconddigital model comprises projecting the second digital model at aholographic display system or producing the second digital model on oneor more of augmented reality, virtual reality, or mixed reality displaysystems.
 18. The computer program product of claim 16, wherein the setof aural, tactile, or olfactory signals associated with the seconddigital model comprises a set of tactile or aural signals and causingthe sensory device to output the set of aural, tactile, or olfactorysignals associated with the second digital model comprises causing ahaptic device comprising a smart wearable device, a smart hand-helddevice, or a haptic vest to produce the set of haptic or aural signalsassociated with the symptom.
 19. The computer program product of claim18, further comprising modulating an intensity, a location, or afrequency of the set of tactile signals.
 20. The computer programproduct of claim 19, wherein the intensity, the location, or thefrequency of the set of tactile signals is modulated to correspond witha third digital model representing a change over time to humanperception in at least a portion of the set of tactile signals, thethird digital model corresponding with one or more of alleviation of thesymptom or data received from a biofeedback device.
 21. The computerprogram product of claim 16, wherein the set of aural, tactile, orolfactory signals associated with the second digital model comprises aset of olfactory signals and causing the sensory device to output theset of aural, tactile, or olfactory signals associated with the seconddigital model comprises causing an olfactory device to produce the setof olfactory signals associated with the symptom.
 22. The computerprogram product of claim 21, wherein the computer-executableinstructions, when executed by the one or more processors, further causethe computer system to modulate at least one of an intensity, aduration, or a fragrance of the set of olfactory signals to correspondwith a third digital model representing symptom alleviation.
 23. Asystem for modeling a symptom of a user, comprising: a display systemconfigured for one or more of holography, virtual reality, augmentedreality, or mixed reality; a speaker; and a computer systemcommunicatively coupled with the display system and the speaker, thecomputer system comprising: one or more processors; and one or morecomputer-readable storage media having stored thereoncomputer-executable instructions that, when executed by the one or moreprocessors, configure the computer system to create a multidimensionalsensory environment comprising a virtual, augmented, mixed reality, orholographic environment and visual and aural sensory signals to model asymptom of a user by causing the computer system to perform at least thefollowing: generate a first digital model within the multidimensionalsensory environment, the first digital model comprising a representationof one or more of a room, a landscape, an avatar, or a virtual controlpanel; cause the display system to produce the first digital model;receive a description of the symptom comprising (i) a size, (ii) asound, or (iii) a color associated with the symptom; receive keycharacteristics of the symptom, the key characteristics comprising oneor more of (a) a frequency, (b) an intensity, (c) a saturation or (d)dimension for one or more of (i) the size, (ii) the sound, or (iii) thecolor associated with the symptom; generate a second digital modelcomprising a set of visual sensory signals and a set of aural sensorysignals, the second digital model being a dynamic representation of thesymptom based on the description and the key characteristics of thesymptom; cause the display system to produce the set of visual sensorysignals of the second digital model at a location within themultidimensional sensory environment; and deliver the set of auralsensory signals associated with the second digital model to the speaker,the set of aural sensory signals customized to match at least the soundassociated with the symptom, as provided by the description and keycharacteristics of the symptom.
 24. The system of claim 23, furthercomprising computer-executable instructions that, when executed by theone or more processors, configure the computer system to further performat least the following: generate a third digital model comprising asecond set of visual sensory signals and a second set of aural sensorysignals corresponding to an alleviation or removal of the symptom basedon the first or the second digital models, wherein the third digitalmodel represents a continuous change over time to human perception in atleast a portion of one or more of the second set of visual sensorysignals or the second set of aural sensory signals; and cause at leastone of: (1) the display system to display the second set of visualsensory signals based on the third digital model, or (2) the speaker togenerate the second set of aural sensory signals based on the thirddigital model.